Year-to-year dynamics of trophic links of the main commercial fishes in the Barents Sea as indicating the state of ecosystem

Ecosystem dynamics and optimal long-term harvest in the Barents Sea fisheries. Proceedings of the 11th Russian-Norwegian Symposium. Murmansk, 15-17 August 2005

Year-to-year dynamics of trophic links of the main commercial fishes in the Barents Sea as indicating the state of ecosystem [presentation]

Ecosystem dynamics and optimal long-term harvest in the Barents Sea fisheries. Proceedings of the 11th Russian-Norwegian Symposium. Murmansk, 15-17 August 2005

Year-to-year dynamics of trophic links of the main commercial fishes in the Barents Sea as indicating the state of ecosystem

Ecosystem dynamics and optimal long-term harvest in the Barents Sea fisheries. Proceedings of the 11th Russian-Norwegian Symposium. Murmansk, 15-17 August 2005

Climate variations and the state of zooplankton in the Barents Sea

We present data on zooplankton biomass distribution in August-September 2005-2006 obtained in the integrated ecosystem system survey for the Barents Sea performed by Russian and Norwegian vessels. In order to establish the general regularities of plankton biomass, data collected in the central latitudinal zone of the Barents Sea in individual years (cold 1987, moderate warm 1989, anomalous warm 2002, 2004, 2005) were analysed. Considerable annual differences in the species and age structure of plankton community in water masses of different origin depending on dynamics of the ice cover in that part of the sea were found. In 2002, owing to the northerly position of the ice edge in summer, the plankton community was characterized by its mixed composition (Atlantic and Arctic species) and high abundance. In 2005 when the advective processes were weak and the eastern areas became free from ice later, a considerable reduction in the abundance of warm-water species was observed. When the position of the ice edge was most southerly in 2004, the bulk of the plankton community was made up of Arctic species and a lack of warm-water species was recorded. In 1987 and 1989, high horizontal gradients of water temperature in the areas of Atlantic and interactions of Arctic water masses were, together with anomalous ice distribution, the main factors influencing the state of zooplankton

20th anniversary of the PINRO-IMR cooperation in the investigations of fish feeding in the Barents Sea: results and perspectives

Since 1986 the Institute of Marine Research, (IMR), Norway and the Knipovich Polar Research Institute of Marine Fisheries and Oceanography (PINRO), Russia, have carried out a joint research program on the trophic relationships in the Barents Sea. As part of this program, the two institutions have exchanged quantitative diet data from fish in the Barents Sea, mainly cod. Diet data can give information about important trophic links in the ecosystem and the strenght of those links. Therefore, diet data is important for quantifying interactions between fish stocks, e.g. by calculating how natural mortality due to predation influences their dynamics. In this paper we give an overview of diet data collected by IMR and PINRO during the last 20 years, and present some results and perspectives for future work

Climate impacts on feeding and condition of capelin Mallotus villosus in the Barents Sea : evidence and mechanisms from a 30 year data set

Paid Open Acces

Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

Albumin binding domain derived affinity proteins (ADAPTs) are a class of small and folded engineered scaffold proteins that holds great promise for targeting cancer tumors. Here, we have extended the in vivo half-life of an ADAPT, targeting the human epidermal growth factor receptor 2 (HER2) by fusion with an albumin binding domain (ABD), and armed it with the highly cytotoxic payload mertansine (DM1) for an investigation of its properties in vitro and in vivo. The resulting drug conjugate, ADAPT6-ABD-mcDM1, retained binding to its intended targets, namely HER2 and serum albumins. Further, it was able to specifically bind to cells with high HER2 expression, get internalized, and showed potent toxicity, with IC50 values ranging from 5 to 80 nM. Conversely, no toxic effect was found for cells with low HER2 expression. In vivo, ADAPT6-ABD-mcDM1, radiolabeled with Tc-99m, was characterized by low uptake in most normal organs, and the main excretion route was shown to be through the kidneys. The tumor uptake was 5.5% ID/g after 24 h, which was higher than the uptake in all normal organs at this time point except for the kidneys. The uptake in the tumors was blockable by pre-injection of an excess of the monoclonal antibody trastuzumab (having an overlapping epitope on the HER2 receptor). In conclusion, half-life extended drug conjugates based on the ADAPT platform of affinity proteins holds promise for further development towards targeted cancer therapy